Zack Wang, Ph.D.
Maine Medical Center Research Institute
81 Research Dr
Scarborough ME, 04074
Phone: (207) 396-8313
Lab Phone: (207) 396-8316
Fax: (207) 396-8379
Zack Zhengyu Wang is a principal investigator in the COBRE in Stem Cell Biology and Regenerative Medicine at the Maine Medical Center Research Institute. He received his Ph.D. at the Boston University School of Medicine in the Department of Biochemistry. His thesis research involved the study of molecular hematopoiesis, focusing on the mechanisms of cell cycle regulation of polyploidy in megakaryocytes, the platelet precursors. He did his postdoctoral training in the laboratory of Dr. David Scadden in the Center of Regenerative Medicine at the Massachusetts General Hospital and Harvard Stem Cell Institute, Boston. His research focused on molecular mechanisms of hematopoietic stem cells and blood vessel development. After leaving an instructor position at Harvard Medical School he joined the MMCRI in 2005. He also directs the FACS and ES Cell Core in the Center for Molecular Medicine.
The long-term research goal of my laboratory is to understand the molecular mechanisms that regulate stem cell self-renewal, and differentiation of hematopoietic and endothelial lineages. Both adult and embryonic stem (ES) cells hold great potential for regenerative medicine, and gene therapy. Defining the molecular links between differentiation outcomes will provide important information for designing rational methods of stem cell manipulation. We will (i) characterize ES cell-derived hematopoietic and endothelial progenitors as a renewable resources for in vivo studies in animal models, (ii) use ES cells as a model system to explore the relationships of vasculogenesis and hematopoiesis, and elucidate the molecular mechanisms that control fate determination, (iii) use mouse model to study microenvironment (niche) of hematopoietic stem cells.
Human ES cell-derived endothelial cells form functional blood vessels in vivo
For a complete list of publications, click here.
Wang ZZ*, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK* and Scadden DT*. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol. 2007; 25:317-8. (*Corresponding authors) (PMID: 17322871)
Chen T, Bai H, Shao Y, Arzigian M, Janzen V, Attar E, Xie Y, Scadden DT and Wang ZZ. Stromal cell-derived factor-1/CXCR4 signaling modifies the capillary-like organization of human embryonic stem cell-derived endothelium in vitro. Stem Cells 2007; 25:392-401. (PMID: 17038674).
Li ZJ, Wang ZZ, Zheng YZ, Xu B, Yang RC, Scadden DT and Han HC. Kinetic Expression of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) during Embryonic Stem Cell differentiation. J Cell Biochem. 2005; 95:559-570. (PMID: 15786495).
Wang Z, Shao Y, Cohen K, Mole P, Dombkowski D and Scadden DT. Ephrin receptor, EphB4, regulates ES cell differentiation of primitive mammalian hemangioblasts, blood, cardiomyocytes, and blood vessels. Blood 2004; 103:100-109. (PMID: 12958066).
Poznansky MC, Olszak IT, Evans RH, Wang Z, Foxall RB, Olson DP, Weibrecht K, Luster AD, and Scadden DT. Thymocyte emigration is mediated by active movement away from stroma-derived factors. J Clin Invest. 2002; 109:1101-10. (PMID: 11956248).
Left to Right: Daniel Moore, Tamara Adams, Melanie Arzigian, Hao Bai, Zack Wang