Ilka Pinz, Ph.D.
Maine Medical Center Research Institute
81 Research Dr
Scarborough ME, 04074
Phone: (207) 396-8280
Lab Phone: (207) 396-0361
Fax: (207) 396-8141
Ilka Pinz received her Ph.D. in physiology at the Alfred-Wegener Institute for Polar and Marine Research, University of Bremen, Germany. She did her postdoctoral training in the NMR laboratory of Dr. Joanne Ingwall at Brigham and Women’s Hospital, Harvard Medical School, Boston. Her research focused on cardiac energy metabolism in several mouse models of heart failure. After leaving a senior research associate/adjunct assistant professorship position at the University of New England she joined MMCRI in 2005 and supports the Magnetic Resonance Imaging Core facility.
The research focus of my laboratory is on mechanisms leading to the development of cardiomyopathy in dyslipidemia. With the growing incidence of obesity, and the burden this puts on the health care system, it is important to understand the mechanisms how certain fatty acids and their metabolites contribute to signalling pathways in cardiomyocytes that cause a decline in contractile performance. In particular, the interaction of fatty acid metabolism and tumor necrosis factor alpha (TNFalpha), a cytokine released by adipocytes and cardiomyocytes, are poorly understood. We utilize transgenic mouse models of dyslipidemia and TNFalpha over-expression to investigate contractile performance in-vivo and of the isolated heart.
Pinz I. & H.O. Pörtner: Metabolic costs induced by lactate in the toad Bufo
marinus: new mechanism behind oxygen dept? J. Appl. Physiol. 2003, 94:
Javadpour M., Tardiff J. C., Pinz I., Ingwall J. S.: Decreased energetics in
murine hearts bearing the R92Q mutation in cradiac troponin T. J. Clin.
Invest. 2003, 112: 768-775
Nascimben L., Ingwall J. S., Lorell B. H., Pinz I., Schultz V., Tornheim K.,
Tian R.: Mechanisms for increased glycolysis in the hypertrophied rat heart.
Hypertension 2004, 44(5): 662-667
Pinz I., Perry D.J., Frederich M.: Activation of 5'-AMP activated protein
kinase during anaerobiosis in the rock crab, Cancer irroratus. Mount Dessert
Island Biological Laboratory Bulletin 2004, 44V
Pinz I., Robbins J., Rajasekaran N.S., Benjamin I.J., Ingwall J.S.:
Unmasking different mechanical and energetic roles for the small heat shock
proteins CryAB and HSPB2 in transgenic mouse hearts. FASEB J. 2008 Jan;
Pinz I, Ostroy SE, Hoyer K, Osinska H, Robbins J, Molkentin JD, Ingwall JS.:
Calcineurin-induced energy wasting in a transgenic mouse model of heart
failure. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3): H1459-66
Pinz I, Wax SD, Anderson P, Ingwall JS: Low over-expression of TNFa in the
mouse heart increases contractile performance via TNFR1. Journal of Cellular
Biochemistry, 2008 May 1st, in press