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9. Who Needs to Review My Research Prior to IRB Submission?

The MMC IRB relies on prior appropriate scientific review of research proposals.  Research involving human subjects is to be reviewed for scientific validity and appropriateness prior to IRB review. 


Exceptions to local scientific review are accepted in the following cases:

  • Federally funded proposals including NIH and
  • All NCI oncology group proposals
  • All FDA regulated industry sponsored clinical trials
  • Local university Master's or Dissertation Council reviewed proposals


However, MMC IRB requires a completed Administrative and Study Review for all proposals, including a signature of the Department Chief (or designee) or Practice Administrator in the case of studies conducted with private practices. See Guidance for Departmental Administrative, Study and Scientific Review Document, Administrative and Study Review Form

and Flow Sheet.


If you plan an investigator-initiated study that carries greater than minimal risk, then your study will need to be reviewed by the Scientific Review Group.  This review will have to take place prior to your submission to the IRB.  Please contact the Office of Research Compliance 396-8182 to receive the details of that process.



Maine Medical Center Research Institute 81 Research Dr Scarborough, ME 04074 (207)396-8100

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