• Research
  • Center for Molecular Medicine
  • Center for Clinical and Translational Research
  • Center for Outcomes Research and Evaluation
  • Center for Psychiatric Research
  • Clinical Trials
  • Vector-borne Disease Laboratory
  • Core Facilities
  • BioBank

COBRE in Stem Cell Biology and Regenerative Medicine

NIH/NIGMS-sponsored COBRE in Stem Cell Biology and Regenerative Medicine (NIH P20GM103465/P20RR18789)

This Center of Biomedical Research Excellence (DM Wojchowski, Director and Principal Investigator) focuses on stem and progenitor cell biology in regenerative contexts. An overall goal is to advance an understanding of key molecular mechanisms that govern stem and progenitor cell renewal, lineage determination, and directed differentiation.

Research projects also each take aim at therapeutic goals:

Dr. Thomas Gridley is characterizing the role of Notch signaling in a novel skeletal myopathy model.

Dr. Kevin Mills has developed novel approaches to discover and characterize chromosomal fragility in cancer contexts

Dr. Leif Oxburgh is working to characterize a novel renal progenitor cell pools with potential regenerative properties

Dr. Clifford Rosen is applying metabolomic approaches to define key molecular regulators of bone and adipocyte formation (including insulin-like growth factor binding protein-2)

Dr. Pradeep Sathyanarayana is investigating the role of novel anti-adhesion, migration factors and unique STAT5 regulated microRNA profiles in Acute Myeloid Leukemia (AML).

Dr. Zack Wang has established an efficient system for the development of hematopoietic, endothelial, and smooth progenitor cells from human ES cells

Dr. Don Wojchowski has discovered novel regulators of erythropoiesis that point to new in-roads for anti-anemia therapies

Dr. Wen-shu Wu has discovered novel anti-apoptotic effects for a SLUG transcriptional repressor in hematopoietic stem cells

Dr. Jeong Yoon is investigating cristins/r-spondins as novel wnt co-factors with therapeutic activities (e.g. bone & muscle development)

Our Stem Cell Biology and Regenerative Medicine Center is further reinforced by strong External and Internal Advisory Steering Committees, and by four expert Core facilities. 

STEM CELL COBRE CORE FACILITIES:

This COBRE also has developed and implemented the following technical cores (click links for details)   

•  Physiology Core, Cliff Rosen, Director
  
•  Histopathology Core, Volkhard Lindner, Director
  
•  Molecular Phenotyping Core, Leif Oxburgh, Director
  
•  Progenitor Cell Analysis Core, Pradeep Sathyanarayana, Co-Director

and Ed Jachimowicz, Co-Director

STEM CELL COBRE EXTERNAL ADVISORY COMMITTEE MEMBERS:

• Peter Besmer, Sloan-Kettering Institute
  
• David Scadden, Harvard University
  
• Leonard Shultz, The Jackson Laboratory
  
• Jeffrey Silva, Cell Signaling Technology, Inc.
  
• Gerald Spangrude, University of Utah, School of Medicine
  

STEM CELL COBRE INTERNAL ADVISORY COMMITTEE MEMBERS:

• Peter Brooks
  
• Robert Friesel
  
• Thomas Gridley
  
• Lucy Liaw
  
• Volkhard Lindner
  
• Kevin Mills
  
• Leif Oxburgh
  
• Clifford Rosen
  
• Pradeep Sathyanarayana
  
• Don St. Germain