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Center for Molecular Medicine

Principal Investigators

CMM Principal Investigators

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Dr Brooks

Peter Brooks, Ph.D.

  • Regulation of integrin-mediated cellular communication with the extracellular matrix (ECM) with angiogenesis, tumor growth and metastasis.

Friesel Thumb

Bob Friesel, Ph.D.

  • Normal and abnormal signal transduction during bone growth and development
  • Identification of novel antagonists of FGF signaling

Dr Gridley

Thomas Gridley, Ph.D.

  • Transcriptional networks involving Snail-family transcriptional repressors
  • The Notch signaling pathway during embryonic development

arturo hernandez, phd maine medical center research institute

Arturo Hernandez, PhD

  • Role of Dio3 in development and in the programming of neuroendocrine function and behavior
  • Epigenetic regulation of Dio3 and its potential role in human disease

Robert Koza, PhD

Robert Koza, PhD

  • Identification of epigenetic determinants of obesity and related metabolic disorders
  • Characterization of novel genes that regulate fat mass expansion

Dr Liaw

Lucy Liaw, Ph.D.

  • Signaling pathways regulating vascular remodeling
  • Cancer biomarkers

Dr Lindner

Volkhard Lindner, M.D. Ph.D.

  • Cthrc1 function and mechanism of action
  • Genes regulating vascular remodeling

Dr Oxburgh

Leif Oxburgh, DVM Ph.D.

  • Identification and characterization of the undifferentiated precursor cells that give rise to the nephron within the developing kidney
  • Signals and genetic programs regulating the differentiation of nephron precursor

Dr Pinz

Ilka Pinz, Ph.D.

  • Mechanisms leading to the development of cardiomyopathy in dyslipidemia

Dr Prudovsky

Igor Prudovsky, Ph.D.

  • The Role of FGF and Jagged in the regulation of angiogenesis
  • Novel mechanisms of protein trafficking

Michaela Reagan, PhD

Michaela Reagan, PhD

  • Cells, factors and pathways supporting the growth of multiple myeloma in the bone microenvironment.
  • Novel technologies: 3-D models, bone-targeting nanomedicine, and clinically relevant in vivo models to study bone metastatic cancers.

Cliff Rosen

Clifford Rosen, MD

  • Genetic regulation of insulin-like growth factor relative to skeletal metabolism
  • Relationship between marrow adipogenesis and osteoblastogenesis

Pradeep Sathyanarayana, PhD

Pradeep Sathyanarayana, Ph.D.

  • Role of Tumor Suppressor & Oncogenic microRNAs in myelopoiesis & Myeloid Leukemia
  • Novel Roles of Podocalyxin in Myelopoiesis and Myeloid Leukemia

Dr Vary


Calvin Vary, Ph.D.

  • Role of endoglin in development and adult vascular diseases including hereditary hemorrhagic telangiectasia
  • TGF-beta receptor-dependent mechanisms in vascular biology and prostate cancer

Dr Wojchowski

Don Wojchowski, Ph.D.

  • Cytokine receptor and transcription factor regulation of hematopoiesis, especially erythropoiesis

Maine Medical Center Research Institute 81 Research Dr Scarborough, ME 04074 (207)396-8100

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