BASIC RESEARCH AREAS

Robert Friesel, Ph.D.

• Normal and abnormal signal transduction during bone growth and development
• Identification of novel antagonists of FGF signaling

Lucy Liaw, Ph.D.

• Murine transgenic approaches to study vascular remodeling
• Tumor growth and blood vessel recruitment

Volkhard Lindner, M.D., Ph.D.

• The biology of high molecular weight FGF-2 complexes
• Characterization of novel genes expressed in the vessel wall

Leif Oxburgh, DVM, Ph.D.

• Identification and characterization of the undifferentiated precursor cells that give rise to the nephron within the developing kidney
• Signals and genetic programs regulating the differentiation of nephron precursors

Ilka Pinz , Ph.D.

• Mechanisms leading to the development of cardiomyopathy in dyslipidemia

Igor Prudovsky, Ph.D.

• The Role of FGF and Jagged in the regulation of angiogenesis
• Novel mechanisms of protein traffic

Doug Spicer, Ph.D.

• Regulation of growth and differentiation of muscle, bone, and endothelial cells
• Transcriptional regulation of mesenchyme formation from the cranial neural crest

Calvin Vary, Ph.D.

• Role of Endoglin in vascular smooth muscle cell regulation and hemorrhagic telangiectasia type 1
• Control of gene expression during differentiation of the osteoblast

Joe Verdi, Ph.D.

• Determining the molecular mechanisms underlying self renewal and lineage specification of multipotential stem cells
• Examining the clonal transdifferentiation of neural precursors into hematopoietic and myogenic lineages

Zack Wang, Ph.D.

• Hematopoietic and endothelial differentiation of embryonic stem (ES) cells
• The molecular mechanisms that control fate determination of vasculogenesis and hematopoiesis

Don Wojchowski, Ph.D.

• Cytokine receptor and transcription factor regulation of hematopoiesis, especially erythropoiesis

Wen-Shu Wu, M.D.

Jeong Yoon, Ph.D.

• Cell fate determination and morphogenesis in vertebrate development