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Joseph
Verdi , Ph.D.
Center for Molecular Medicine
Maine
Medical Center Research Institute
81 Research Drive
Scarborough, ME 04074
verdij@mmc.org |
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Biosketch
Joseph
M. Verdi received his Ph.D. from the University of California
at Los Angeles in 1991. He obtained postdoctoral training in
Developmental Neuroscience at the California Institute of Technology.
Dr. Verdi joined the Center for Molecular Medicine at Maine
Medical Center Research Institute in 2002 after five years
as the Director of the Laboratory of Neural Stem Cell Biology
Laboratory, John P. Robarts Research Institute, and Assistant
Professor, Department of Physiology and Genetics, Graduate
Program in Neuroscience, University of Western Ontario, London,
Ontario, Canada. Dr. Verdi has served as director, consultant
and member of several medical and scientific committees. |
Research
Interests
I
have had a long-standing passion for elucidating the mechanism
that regulates normal development and applying that knowledge
to understanding what goes astray in disease. My laboratory
currently focuses on three questions of paramount importance
within the stem cell field. They are: describing the molecular
and signaling events underlying instructive factor lineage
restriction using neural crest stem cells and central nervous
system stem cells as model systems; the mechanism underlying
neural stem cell plasticity, i.e. elucidating the molecular
mechanism by which neural stem cells differentiate into non-neural
lineages or the molecular mechanism by which hematopoietic
stem cells become neural tissue, and the identification of
genes, factors and signaling pathways involved in asymmetric
(lineage restriction) versus symmetric (self renewal) stem
cell division. Our laboratory has made reasonable progress
into answering each of these questions by successfully describing
the factors, receptors, signaling pathways and mechanisms that
direct normal stem cell development. |
Selected
Publications
Meakin,
S.O., MacDonald, J.I.S. Gryz, E.A., Kubu, C.J., and Verdi,
J.M. The
signaling adapter FRS-2 competes with shc for binding to the
nerve growth factor receptor TrkA: A model for discriminating
proliferation and differentiation J. Biol. Chem., 1999;
274: 9861-9870.
Verdi,
J.M., Bashirullah, A., Goldhawk, D., Meakin, S.O., and Lipshitz,
H.D. Distinct
human NUMB isoforms regulate differentiation versus proliferation
in the neuronal lineage. Proc. Natl. Acad. Sci., 1999;
96: 10472-10476.
MacDonald,
J.I.S., Verdi , J.M., and Meakin, S.O. Activity-dependent
interaction of the intracellular domain of rat trkA with intermediate
filament proteins, the beta-6 proteasomal subunit, Ras-GRF1
and the p162 subunit of eIF3. J. Mol. Neurosci., 1999;
13: 141-158.
Morrison,
S.J, Perez, S.E., Qiao, Z., Verdi, J.M., Hicks, C., Weinmaster,
G., and Anderson, D.J. (2000) Transient
Notch activation initiates an irreversible switch from neurogenesis
to gliogenesis by neural crest stem cells. Cell. 101: 499-510.
White,
P.M., Morrison, S.J., Orimoto, K., Kubu, C.J., Verdi, J.M.,
and Anderson, D.J. (2001) Neural
crest stem cells undergo cell-intrinsic developmental changes
in sensitivity to instructive differentiation signals. Neuron
29: 1-20.
Bhattacharya,
M., Anborgh, P.H., Babwah, A.V., Eccelstone, J. Dale, L.B.,
Dobransky, T., Barlic, J., Rylett, R.J., Feldman, R.D., Verdi,
J.M and Ferguson, S (2002) beta-arrestin
regulates RalGDS-Ral effector pathway mediating cytoskeletal
reorganization and granule release. Nature Cell Biol. 8:
547-555.
Kubu,
C.J., Orimoto, K., Morrison, S., Weinmaster, G., Anderson,
D.J., and Verdi, J.M. (2002) The
loss of neurogenic potential of neural stem cells during development
is correlated with an increase in notch signaling and gliogenic
potential. Dev. Biol. 244: 199-214.
Zhou,
L., McDougall, K., Kubu, C., Verdi, J.M. and Meakin, S.O. Genomic
Organization and Comparative Analysis of the Mouse and Human
FRS2, FRS3 Genes. Molecular Biology Reports 2003; 30:15-25.
Kendall,
S.E., Ryczko, M.C., Mehan, M. and Verdi, J.M. Characterization
of NADE, NRIF and SC-1 Gene Expression During Mouse Neurogenesis. Dev.
Brain Res., 2003;144(2):151-8 |
Lab
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