This
program focuses on developmental and disease processes in the vascular
system. The program was started in 2000 with an emphasis
on angiogenesis. The scope of the program was expanded to vascular
biology when renewed in 2005. The major goal is to reveal the
molecular mechanisms that regulate vascular development and remodeling
after injury, mechanisms of inflammation, and angiogenesis. Individual
projects are aimed at basic discoveries that have translational potential. Dr.
Lindner has discovered a novel protein that regulates fibrosis in the
vasculature and several organ systems; Dr. Liaw is studying the role
of the Notch pathway in the development of gastrointestinal tumors
which are hypothesized to be of smooth muscle cell origin; Dr. Vary
has revealed a novel TGF-beta signaling pathway in vascular development;
Dr. Prudovsky is elucidating the pathway for the secretion of the inflammatory
mediator IL1; and Dr.Pinz has established a system to examine the
effects various lipids on cardiac function. These projects are
supported by outstanding core facilities funded in part through the
COBRE program of the NCRR.
COBRE
faculty:
Robert
Friesel (Director)
Peter Brooks
Lucy
Liaw
Volkhard
Lindner
Ilka
Pinz
Igor
Prudovsky
Douglas Spicer
Calvin
Vary
Jeong
Yoon
Sites
with links or information on other NIH
IDeA Programs funded by the NCRR
