This program (NIH/NCRR P20RR18789) focuses on Stem and Progenitor Cell Biology in regenerative contexts. An overall goal is to advance an understanding of key molecular mechanisms that govern stem and progenitor cell renewal, lineage fate, and directed differentiation.
Each project takes aim at therapeutic goals:
Dr Oxburgh is working to characterize a novel renal progenitor cell pools with potential regenerative properties;
Dr Wang has established an efficient system for the development of hematopoietic, endothelial, and smooth progenitor cells from human ES cells;
Dr Yoon is investigating cristins/r-spondins as novel wnt co-factors with therapeutic activities (e.g. bone & muscle development);
Dr Mills has developed novel approaches to discover and characterize chromosomal fragility in Cancer contexts;
Dr Verdi is defining Notch-orthologue activities that sustain neural progenitor cell potency;
Dr Wu has discovered novel anti-apoptotic effects for a SLUG transcriptional repressor in hematopoietic stem cells;
Dr Wojchowski has discovered novel regulators of erythropoiesis that point to new in-roads for anti-anemia therapies.
Our Center is further reinforced by strong External and Internal Advisory Steering Committees, and by established technical cores in Flow Cytometry and Progenitor Cell Analysis; Histopathology; Bioinformatics & Genomic; and Embryonic Stem (ES) and Cell Separation.
COBRE
faculty:
Don
Wojchowski (Director)
Leif Oxburgh
Jeong
Yoon
Zack
Wang
Kevin Mills
Wen-Shu Wu
Joe Verdi
Volkhard Lindner
EXTERNAL ADVISORY COMMITTEE:
Hal Broxmeyer, Walther Oncology Center, Indiana Univ. School of Medicine
Peter Besmer, Sloan-Kettering Institute
Thomas Gridley, The Jackson Laboratory
Gerald Spangrude, Univ. Utah School of Medicine
David Williams, Harvard Medical School and Children’s Hospital Boston
INTERNAL ADVISORY COMMITTEE:
Robert Friesel
Clifford Rosen
Kenneth Ault
Peter Brooks
Arthur Lage
Lucy Liaw
Volkhard Lindner
Joseph Verdi
