Clifford J. Rosen, M.D.

Senior Scientist, Maine Medical Center Research Institute
(207) 662-4174 Office
(207) 662-6326 Fax
rosenc@mmc.org

Biosketch

Dr. Clifford J. Rosen, M.D. is currently a Senior Scientist at Maine Medical Center’s Research Institute. He is the Former Director of the Maine Center for Osteoporosis Research and Education an affiliate of St. Joseph Hospital, a Center which he started over 15 years ago. He currently oversees over 12 clinical research trials both Pharmaceutical and NIH funded studies. He is also Past President of the American Society of Bone and Mineral Research (ASBMR) 2002 – 2003. He also works as a Senior Staff Scientist at the Jackson Laboratory in Bar Harbor Maine studying IGF, IGFBPs on inbred strains of mice. He served 5 years as the first editor in Chief of the Journal of Clinical Densitometry the official Journal of the International Society of Clinical Densitometry. And currently serves as Associate Editor on the Journal of Bone and Mineral Research. His publications exceed 275 manuscripts published in a variety of Journals.

Research Interests

Coming soon!

Selected Publications

Sellmeyer DE, Black DM, Palermo L, Greenspan S, Ensrud K, Bilezikian J, Rosen CJ 2007 Hetereogeneity in skeletal response to full-length parathyroid hormone in the treatment of osteoporosis. Osteoporos Int 18:973-979

Lecka-Czernik B, Ackert-Bicknell C, Adamo ML, Marmolejos V, Churchill GA, Shockley KR, Reid IR, Grey A, Rosen CJ 2007 Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by rosiglitazone suppresses components of the insulin-like growth factor regulatory system in vitro and in vivo. Endocrinology 148:903-911

Recker R, Lips P, Felsenberg D, Lippuner K, Benhamou L, Hawkins F, Delmas PD, Rosen C, Emkey R, Salzmann G, He W, Santora AC 2006 Alendronate with and without cholecalciferol for osteoporosis: results of a 15-week randomized controlled trial. Curr Med Res Opin 22:1745-1755

Beamer WG, Shultz KL, Ackert-Bicknell CL, Horton LG, Delahunty KM, Coombs HF, Donahue LR, Canalis E, Rosen CJ 2007 Genetic Dissection of Mouse Distal Chromosome 1 Reveals Three Linked BMD QTL With Sex Dependent Regulation of Bone Phenotypes. J Bone Miner Res 22:1187-1196

Black DM, Rosen CJ 2007 Is risedronate or alendronate more effective at preventing nonvertebral fractures in women with osteoporosis? Nat Clin Pract Rheumatol 3:378-379

Shockley KR, Rosen CJ, Churchill GA, Lecka-Czernik B 2007 PPAR2 Regulates a Molecular signature of Marrow Mesenchymal Stem Cells. PPAR Research In Press:

Ackert-Bicknell CL, Salisbury JL, Horowitz M, DeMambro VE, Gorton LG, Shultz KL, Lecka-Czernik B, Rosen CJ 2007 A Chromosomal Inversion Within A Quantitative Trait Locus Has a Major Effect on Adipogenesis and Osteoblastogenesis. Ann. N.Y. Acad. Sci. xxx:1-55 DOI:10.1196/annals.1402.010 In Press

Flood A, Mai V, Pfeiffer R, Kahle L, Remaley AT, Rosen CJ, Lanza E, Schatzkin A 2007 The effects of a high-fruit and -vegetable, high-fiber, low-fat dietary intervention on serum concentrations of insulin, glucose, IGF-I and IGFBP-3. Eur J Clin Nutr, May 9.

Rosen CJ 2007 The Rosiglitazone Story – Lessons from an FDA Advisory Committee Meeting. N Engl J Med www.nejm.org August 8, 2007 10.1056/NEJMPO78167