Thomas D. Nolin, PharmD, PhD

Clinical Pharmacologist
Department of Medicine
Division of Nephrology and Transplantation
and Department of Pharmacy Services
Maine Medical Center
22 Bramhall Street
Portland, ME 04102
(207) 662-3281 Office
(207) 662-3883 Fax
nolint@mmc.org

Biosketch

Tom Nolin, PharmD, PhD, is a clinical pharmacologist in the Maine Medical Center Division of Nephrology and Transplantation.  He received his B.S in Pharmacy from the University of Connecticut, his M.S. in Pharmacy from the University of North Carolina at Chapel Hill, and his PharmD from the University of Pittsburgh.  Dr. Nolin received his PhD in Clinical Pharmaceutical Sciences from the University of Pittsburgh with concentration in the area of drug metabolism/pharmacokinetics.  Dr. Nolin joined Maine Medical Center upon completion of his PhD in 2003.  He serves on several committees, and maintains an active clinical practice and an independent clinical research program.

Research Interests

Dr. Nolin’s research involves characterizing the effect of kidney disease (KD) on the pharmacokinetic properties of drugs.  In particular, his work focuses on developing an understanding of the impact of KD on drug metabolism and transport, and identifying mechanisms by which KD contributes to derangements in these elimination pathways.  His research has led to the development of novel analytical techniques and the creation of population pharmacokinetic models, which have been used to support the characterization of cytochrome P450 activity in patients with chronic kidney disease.

Selected Publications

Nolin TD, McMenamin ME, Himmelfarb J. Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stress.  J Chromatogr B Analyt Technol Biomed Life Sci 2007; 852(1-2):554-61. Epub 2007 Feb 21.Owens RC Jr,

Nolin TD. Antimicrobial-associated QT interval prolongation: pointes of interest.  Clin Infect Dis 2006; 43(12):1603-11. Epub 2006 Nov 8.

Nolin TD, Appiah K, Kendrick SA, Le P, McMonagle E, Himmelfarb J. Hemodialysis acutely improves hepatic CYP3A4 metabolic activity.  J Am Soc Nephrol 2006; 17(9):2363-7. Epub 2006 Aug 9.

Nolin TD, Lambert DA, Owens RC Jr. Stability of cefepime and metronidazole prepared for simplified administration as a single product.  Diagn Microbiol Infect Dis 2006; 56(2):179-84. Epub 2006 Jun 12.

Nolin TD, Gastonguay MR, Bies RR, Matzke GR, Frye RF. Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies.  Clin Pharmacol Ther 2003; 74(6):555-68.

Nolin TD, Frye RF, Matzke GR. Hepatic drug metabolism and transport in patients with kidney disease.  Am J Kidney Dis 2003 Nov;42(5):906-25.

Nolin TD, Frye RF. Stereoselective determination of the CYP2C19 probe drug mephenytoin in human urine by gas chromatography-mass spectrometry.  J Chromatogr B Analyt Technol Biomed Life Sci 2003; 783(1):265-71.

Nolin TD, Colaizzi IV, Palevsky PM, Matzke GR, Frye RF. Rapid microtiter plate assay for determination of inulin in human plasma and dialysate.  J Pharm Biomed Anal 2002; 28(2):209-15.