James C M Chan, MD

Professor of Pediatrics
University of Vermont
Director of Research
The Barbara Bush Children's Hospital
Maine Medical Center
Portland, ME 04102-3175.
(207) 662-2439 Tel
(207) 662-6272 Fax chanj@mmc.org

Biosketch

Born and educated in Hong Kong, Dr. Chan earned his medical degree and completed internship, all at McGill University in Montreal.  He was trained in pediatrics at the Mayo Clinic and pediatric nephrology at Oregon and Columbia universities.  Faculty appointments followed at the University of Southern California, George Washington and Virginia Commonwealth universities, with sabbaticals at the National Institutes of Health (NIH) in 1977 and 1988.  In 2002, he joined the faculty at the University of Vermont and Maine Medical Center (MMC) in Portland where he teaches, writes and conducts research.  He serves on two MMC committees to nurture clinical research.  His research projects on vitamins D and E in childhood kidney diseases and his training program have been funded by three RO1 and two T32 NIH grants.  He has published close to 400 scientific papers and several books including Kidney Electrolyte Disorders. 

Research Interests

• IgA nephropathy and antioxidants
• Renal tubular acidosis and growth failure
• Hematuria
• Focal glomerulosclerosis
• Nephrotic syndrome
• Progressive kidney diseases

Selected Publications

Chan W, Valerie KC, Chan JCM:  Expression of insulin-like growth factor-I in uremic rats: Growth hormone resistance and nutritional intake.  Kidney Int 1993;43:790-795.

Metzger DL, Kerrigan JR, Krieg RJ Jr, Chan JCM, Rogol AD:  Alterations in the neuroendocrine control of growth hormone secretion in the uremic rat.  Kidney Int 1993;43:1042-1048

Challa A, Krieg RJ Jr, Thabet MA, Veldhuis JD, Chan JCM:  Metabolic acidosis inhibits growth hormone secretion in rats: Mechanism of growth retardation.  Am J Physiol 1993;265:E547-E553.

Thabet MAEH, Challa A, Chan JCM, Pandak WM, Heuman DM, Vlahcevic ZR: Studies of alteration of hepatic cholesterol metabolism in puromycin induced nephrotic syndrome in rats.  Kidney Int 1993;44:789-794.

Challa A, Chan W, Krieg RJ Jr, Thabet MA, Liu F, Hintz RL, Chan JCM:  Effect of metabolic acidosis on the expression of insulin-like growth factor and growth hormone receptor.  Kidney Int 1993;44:1224-1227.

Chan JCM, McEnery PT, Chinchilli VM, Abitbol CL, Boineau FG, Friedman AL, Lum GM, Roy S III, Ruley EJ, Strife CFL:  A prospective, double-blind study of growth failure in children with chronic renal insufficiency and the effectiveness of treatment with Calcitriol versus Dihydrotachysterol.  J Pediatr 1994; 124:520-528.

Pandak WM, Vlahcevic ZR, Heuman DM, Krieg RJ Jr, Hanna JD, Chan JCM:  Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl co-enzyme A reductase and cholesterol 7-hydroxylase in rats with subtotal nephrectomy. Kidney Int 1994; 46:358-364.

Hanna JD, Santos F, Foreman JW, Chan JCM, Han VKM:  Insulin-like growth factor-1 gene expression in the tibial epiphyseal growth plate of growth hormone treated uremic rats.  Kidney Int 1995; 47:1375-1382.

Krieg RJ Jr, Tokieda K, Chan JCM, Veldhuis JD: Impact of uremia on female reproductive cyclicity, ovulation, and luteinizing hormone in the rat.  Kidney Int 2000; 58:569-574.

Chan JCM, Mahan JD, Trachtman H, Scheinman J, Flynn JT, Alon US, Lande MB, Weiss RA, Norkus EP:  Vitamin E therapy in IgA nephropathy:  a double-blind, placebo controlled study.  Pediatr Nephrol 2003; 18: 1015-1019.